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ID: 72302 • Letter: H
Question
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The graph to the right shows how the excretion rate and
filtered load of a freely-filtered drug changes as the plasma
concentration of the drug increases. The drug is not
metabolized by the kidney. Use this information to answer
the following questions.
What is the GFR?
What is the Tm of the drug?
Which of the following terms best describes how the renal
tubules handle this drug (circle one answer)
Net Secretion Net Reabsorption No Net Transport
Explanation / Answer
Glomerular filtration rate (GFR) is the volume of liquid separated from the renal (kidney) glomerular vessels into the Bowman's capsule per unit time. Integral to the physiologic upkeep of GFR is the differential basal tone of the afferent and efferent arterioles. As it were, the filtration rate is subject to the distinction between the higher blood pressure made by vasoconstriction of the input or afferent arteriole versus the lower blood pressure strain made lesser vasoconstriction of the yield or efferent arteriole.
Glomerular filtration rate (GFR) is equivalent to the Clearance Rate when any solute is unreservedly separated and is neither reabsorbed nor secreted by the kidneys. The rate in this way measured is the amount of the substance in the urine that began from a measurable volume of blood. Relating this standard to the underneath mathematical statement - for the substance utilized the product of excretion rate and filtered load measures up to the mass of substance discharged amid the time that urine has been collected. This mass equivalents the mass separated at the glomerulus as nothing is included or uprooted in the nephron. Dividing this mass by the plasma concentration gives the volume of plasma which the mass must have initially originated from, and along these lines the volume of plasma fluid that has entered Bowman's capsule inside of the previously stated timeframe. The GFR is ordinarily recorded in units of volume per time, e.g., milliliters every minute mL/min. Contrast with filtration part.
GFR= excretion rate and filtered load/ Plasma concentration
There are a few unique strategies used to calculate or estimate the glomerular filtration rate (GFR or eGFR). The above mathematical expression applies for GFR calculation when it is equivalent to the Clearance Rate.
“” TM” is the words, names, trademarks, pictures or images that are utilized to recognize the wellspring of a specific organization's drug.
A lot of drugs are removed by tubular secretion
Net Secretion Net Reabsorption No Net Transport
On the off chance that, for instance, a drug's renal clearance is measured alongside a valid marker of GFR, and the drug's renal clearance surpasses GFR, then one can dependably infer that the drug of interest has a secretory segment of disposal. Such information don't reject filtration or reabsorption and don't evaluate the secretory segment, yet they do permit the conclusion that secretion happens
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