Human ABO blood groups are controlled by a single gene with three alleles, I A,

Question

Human ABO blood groups are controlled by a single gene with three alleles, I A, I B, and I. The three alleles contribute to four blood group phenotypes. In addition to the ABO blood groups, there are two other loci that control blood phenotypes, the MN blood group locus and the Rh factor locus. The MN blood group has two codominant alleles, L M and L N. The Rh factor also has two alleles, Rh+ and Rh-, where Rh+ is dominant. The two phenotypes at the Rh factor locus are Rh+ and Rh-.
Suppose in a population, the frequency of the ABO allele I A is 0.36 and the I B allele frequency is 0.26. In the same population, the frequency of the L M allele is 0.47, and the frequency of the Rh+ is 0.62.
Map alleles Human ABO blood groups are controlled by a single gene with three alleles A, iB, and i. The three contribute to four blood group phenotypes. In addition to the ABO blood groups, there are two other loci that control blood phenotypes, the MN blood group locus and the Rh factor locus. The M has two codominant alleles, LMand LN The Rh factor locus also has two alleles, Rh and Rh, where Rh is dominant. The two phenotypes at the Rh factor locus are Rh and Rh: N blood group Suppose in a population, the frequency of the ABO allele n is 0.36, and theallele frequency is 0.26. In the same population, the frequency of the LM allele is 0.47, and the frequency of the Rh'is 0.62. What is the frequency of the genotype e LMM Rh'Rh if the population is in Hardy-Weinberg equilibrium? Number

Explanation / Answer

Simply multiply all the individual frequencies.

IAIB LMLM Rh-Rh- = 0.36 * 0.26 * 0.47 *0.47 * 0.38 * 0.38 ~3 * 10-3.

This means that 3 persons out of 1000 will have such a genotype.

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