MICROFILAMENTS A. What monomer comprises microfilaments? Include a description o

Question

MICROFILAMENTS

A.What monomer comprises microfilaments? Include a description of its structure.

B. How are the monomers assembled into microfilaments? Include the role of ATP and ATP hydrolysis in microfilament assembly. How is this similar to microtubule assembly? How does it differ?

C. List the cellular functions are associated with microfilaments.

D. Explain the role that thymosin and profilin play in regulating microfilament assembly.

E. For each of the proteins below that are associated with actin microfilaments, briefly describe their function.

Gelsolin

Fimbrin

Alpha-actinin

Filamin

Myosins

Explanation / Answer

A. Microfilaments are composed of monomers of small proteins known as actin. Microfilaments are one of the cytoskeleton fibers that provides strength, rigidity, and shape to the cell. Actin subunits form a intertwined strands that have a diameter of about 7 nm. They utilize ATP to form the assembly. They can disassemble and reassemble quickly, thus enables the cell to changes its shape and movement.

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