Would the chemical modification change the overal charge on the peptide at pH 7?

Question

Would the chemical modification change the overal charge on the peptide at pH 7? Match the items in the left column to the appropriate blanks in the sentences on the right. oup Reset Help The ( charge on amines is neutralized by acetylation; thus, there is a(n) negatively chargehare n charge when a protein is treated with acetic anhydride. At pH-7 the thiol of cysteine is mosty : thus, addition of negatively-charged carboxymethyl groups will result in )charge density. Phosphorylation at pH 7 will increase increased ( decrease positively charged uncharged increase charge density since hydroxyl groups are at physiological pH

Explanation / Answer

The answer is..................

The (+) charge on amines.................. thus there is a decrease in charge density........... .

At PH=7,the thiol of cysteine is mostly protonated uncharged; Thus addition of ... carboxymethyl group ..... in increase in (-) chargedensity. Phosporylation at PH=7, will increase (-) charge density since hydroxyl groups are uncharged at ....... .

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