Which of the following statements is consistent with how a lipid bilayer may int

Question

Which of the following statements is consistent with how a lipid bilayer may interact with the OmpF porin (1OPF)?

Hint: (1OPF) is the entry ID of Ompf on Protein database and here is the link for Ompf on PDB website: to help with finding the answer:

http://www.rcsb.org/pdb/explore/explore.do?structureId=1OPF

1. The phospholipid groups from both leaflets of the bilayer interact with the top and bottom polar regions of OmpF, while the hydrophobic core of the bilayer noncovalently interacts with the middle regions of the protein exterior through van der Waals interactions.

2. The phospholipid groups from only one side of the bilayer interact with the polar regions of OmpF, while the hydrophobic core of the bilayer noncovalently interacts with the middle regions of the protein exterior through van der Waals interactions.

3. The phospholipid groups from both leaflets of the bilayer interact with the top and bottom polar regions of OmpF, while the hydrophobic core of the bilayer noncovalently interacts with the middle regions of the protein exterior mainly through hydrogen bonds.

4. The phospholipid groups from only one side of the bilayer interact with the polar regions of OmpF, and the remaining components of the protein are exposed to the cytosol.

Explanation / Answer

ANSWER IS " 3 "

Elucidating in Vivo Structural Dynamics in Integral Membrane Protein by Hydroxyl Radical Footprinting.

PUBLISHED IN 2009 IN MOLECULAR CELL PROTEOMICS.

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