Select the event that is essential for the transcription of the immunoglobulin l

Question

Select the event that is essential for the transcription of the immunoglobulin light-chain gene. In the choices below, V is the variable region, C is the constant region, and J is the joining region of the light-chain gene.

a.Somatic mutations in the V region alter the DNA sequence.

b.The leader sequence is cleaved off from the V region.

c.Imprecise recombination at the site of VJ fusion produces hypervariable regions.

d.The C and VJ regions are brought together by removal of exons by RNA splicing.

e. The promoter is brought closer to the enhancer by somatic rearrangements.

Explanation / Answer

The correct answer is option (e).

e. The promoter is brought closer to the enhancer by somatic rearrangements.

The structure of antibody consists of two heavy chains and two light chains which are held by disulphide bonds. The V(D)J recombinations occur in developing lymphocytes. This takes place during the early stages of T and B cell maturation. Somatic recombination is the main step asit involves in high diversity of antibodies. The promoter is brought closer to the enhancer by somatic rearrangements.

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