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Which of the following would be the most common “core” genetic signature associa

ID: 71011 • Letter: W

Question

Which of the following would be the most common “core” genetic signature associated with the majority of advanced, metastatic, human tumors irrespective of their origin? (+) = wild-type, (-) = loss-of-function allele, (DN) = Dominant Negative allele

Bcr-Abl/Abl+ & NF1–/NF1–

RasD/Ras+ & NF1–/NF1–

RasD/Ras+ & Neu/Her2+

RasD/Ras+ & p53DN/p53+

RasD/Ras+ & p53–/p53–

A.

Bcr-Abl/Abl+ & NF1–/NF1–

B.

RasD/Ras+ & NF1–/NF1–

C.

RasD/Ras+ & Neu/Her2+

D.

RasD/Ras+ & p53DN/p53+

E.

RasD/Ras+ & p53–/p53–

Explanation / Answer

RasD/Ras+ & p53–/p53– is the most common “core” genetic signature associated with the majority of advanced, metastatic, human tumors irrespective of their origin

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