The following genotypes are found in the following frequencies in a Chinese popu
ID: 70943 • Letter: T
Question
The following genotypes are found in the following frequencies in a Chinese population: If the frequencies for the first five STRs are the same for an Indian population, but the frequency for the 6th is 0.2 and that for the 7th is 0.1, calculate the probability that an Indian person will match that genotype? Which of the following couples is more likely to be the parents of the given person? 114/114; 222/222; 96/96; 124/124; 200/200; 77/77; 171/174. 114/114; 222/222; 96/96; 108/108; 210/215; 77/77; 171/171. 114/114; 222/222; 96/100; 120/120; 210/215; 71/71; 171/174. 112/112; 222/234; 96/96; 108/124; 210/210; 77/77; 171/171. 112/112; 234/234; 96/96; 108/108; 210/210; 71/71; 171/171. 112/114; 222/234; 96/100; 120/120; 210/210; 77/77; 176/176. Potential Fathers: Potential MothersExplanation / Answer
* Since the first five STRs are same for Indian and Chinese population, only the last two are considered for counting the probability.
According to product rule, the probability can be calculated as follows:
The probability is 0.0236.
Offspring
112/114
222/234
96/96
108/120
210/215
71/77
171/174
Probable mothers
1
114/114
222/222
96/96
124/124
200/200
77/77
171/174
2
114/114
222/222
96/96
108/108
210/215
77/77
171/171
3
114/114
222/222
96/100
120/120
210/215
71/71
171/174
Probable Fathers
1
112/112
222/234
96/96
108/124
210/210
77/71
171/171
2
112/112
234/234
96/96
108/108
210/210
71/71
171/171
3
112/114
222/234
96/100
120/120
210/210
77/77
176/176
(Indicated in black are odds of probability of the person to be parents of the given individual)
When probable fathers and mothers are sorted out, it is obvious that person 1 in probable mothers and person 3 in probable fathers does not match with the genotype of the offspring given. These two options are eliminated
Probable mother 2 could not contribute to the STR 174, since it is present only in probable mother 3. Therefore, probability of person 2 be mother can be eliminated
Therefore, only person 3 has the probability to be the mother
Since the offspring contain the STR genotype 71/77, it is obvious that the allele 71 is inherited from the mother. The only person from whom the offspring can inherit the allele 77 is probable father 1
Therefore, the parents of the given person are Mother-3 and Father 1
Offspring
112/114
222/234
96/96
108/120
210/215
71/77
171/174
Probable mothers
1
114/114
222/222
96/96
124/124
200/200
77/77
171/174
2
114/114
222/222
96/96
108/108
210/215
77/77
171/171
3
114/114
222/222
96/100
120/120
210/215
71/71
171/174
Probable Fathers
1
112/112
222/234
96/96
108/124
210/210
77/71
171/171
2
112/112
234/234
96/96
108/108
210/210
71/71
171/171
3
112/114
222/234
96/100
120/120
210/210
77/77
176/176
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