1) The composition of the infant body, in terms of water content (by percent tot

Question

1) The composition of the infant body, in terms of water content (by percent total mass), and fat content (by percent total mass), changes dramatically in the firt year of life. These changes are most closely linked to which of the following:
a. Drug absorption
b. Drug distrybution
c. Metabolism
d. Excretion
e. Pharmacodynamics
2) It is common for elderly patients to have altered ratios of free-to-bound drug in their blood, because of either reduced serum binding proteins (e.g., albumin) or an increase in serum glycoproteins (which bind to basic drugs). Which of the following is true?
a. A higher ratio of free drug in patient plasma means that the drug will be more potent.
b. A lower ratio of free drug in patient plasma means that drug toxicity is likely.
c.A higher ratio of free drug will likely lead to a greater drug effect at lower plasma concentrations.
d. B and C
e. A and C 1) The composition of the infant body, in terms of water content (by percent total mass), and fat content (by percent total mass), changes dramatically in the firt year of life. These changes are most closely linked to which of the following:
a. Drug absorption
b. Drug distrybution
c. Metabolism
d. Excretion
e. Pharmacodynamics
2) It is common for elderly patients to have altered ratios of free-to-bound drug in their blood, because of either reduced serum binding proteins (e.g., albumin) or an increase in serum glycoproteins (which bind to basic drugs). Which of the following is true?
a. A higher ratio of free drug in patient plasma means that the drug will be more potent.
b. A lower ratio of free drug in patient plasma means that drug toxicity is likely.
c.A higher ratio of free drug will likely lead to a greater drug effect at lower plasma concentrations.
d. B and C
e. A and C 1) The composition of the infant body, in terms of water content (by percent total mass), and fat content (by percent total mass), changes dramatically in the firt year of life. These changes are most closely linked to which of the following:
a. Drug absorption
b. Drug distrybution
c. Metabolism
d. Excretion
e. Pharmacodynamics
2) It is common for elderly patients to have altered ratios of free-to-bound drug in their blood, because of either reduced serum binding proteins (e.g., albumin) or an increase in serum glycoproteins (which bind to basic drugs). Which of the following is true?
a. A higher ratio of free drug in patient plasma means that the drug will be more potent.
b. A lower ratio of free drug in patient plasma means that drug toxicity is likely.
c.A higher ratio of free drug will likely lead to a greater drug effect at lower plasma concentrations.
d. B and C
e. A and C

Explanation / Answer

1.C) metabolism which is related to the physical activities of the child.

2.E) A higher ratio of free drug in patient plasma makes it more potent and especially at lower plasma concentrations.

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