cell adhesion can often be bocked by treating cells with spesific agents. which
ID: 70756 • Letter: C
Question
cell adhesion can often be bocked by treating cells with spesific agents. which of the following sustances,agenst, woud e expected to interfere with cell adhesion mediated by the molecules below. exolain your answers by choosing substances for each of the cell adhesion molecules below. more than one suctances may apply for each adhesion molecule- explain why you chose each sucstances.
cell adhesion molecules: a) L1 molecules, b) cadherins, c) integrins
substances: 1) trupsin, whcih digest proteins ,2) neuraminidase, which removes sialit acid from an oligosaccharide, 3) collagenase, whcih digests collage, 4) hyaluronidase, which digests hyaluronic asid, 5) EGTA, whihc binds Ca+2 ions in the medium
Explanation / Answer
The protein molecules, which connect the cells and extracellular matrix, are called cell adhesion molecules. These molecules play an important role in cell-to-cell communication and they are categorized into two major groups, namely Calcium-independent and Calcium-dependent. For example, in simple glycoproteins, protein constituent gives major weight and they act in binding of sperm to egg and cell adhesion.
The following substances would be expected to interfere with cell adhesion mediated by the molecules below:
a) L1 molecule: It is a neuronal transmembrane cell adhesion protein and it is also called CD171. It belongs to immunoglobulin super family and involved in neuronal development.
b) Cadherins: It is a Ca+2 binding protein. So, inhibition of calcium can inactivate the cadherins.
c) Integrins:
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