Question IV. You want to establish an experimental model to investigate complica

Question

Question IV. You want to establish an experimental model to investigate complications of blood transfusion. Thus, you immunize mice with a recombinant strain of Escherichia coli. This recombinant strain of Escherichia coli has been engineered to express a pattern of glycans normally found only on murine erythrocytes. One week after this immunization, you discover that the immunized mice are severely anemic. This observation can be best explained by the fact that [complete the sentence and assess each subsequent statement (36-39) as either factually correct (= “true”) or incorrect

(= “false”)]:

ONLY ONE OF THESE ANSWERS CAN BE TRUE.

36. B cells in the immunized mice started to produce IgM antibodies, which bind to their own erythrocytes and induce complement-mediated lysis.

37. by immunizing the mice with a bacterium containing a self antigen, you have induced high levels of apoptosis in their developing B cells.

38. B cells in the immunized mice started to produce IgG antibodies, which bind to their own erythrocytes and induce Fc-receptor mediated uptake by phagocytes.

39. by immunizing the mice with a bacterium containing a self antigen, you have induced B cell somatic hypermutation and affinity maturation leading to splenomegaly.

ONLY ONE OF THESE ANSWERS CAN BE TRUE.

Explanation / Answer

36 may be factually true because IgM is a poten activator of classical complement pathway abd autoimnuby hemolytic anemia involving IgM is characterised by complement mediated lysis of RBCs.

Related Questions

Navigate

• Browse (All)
• Browse Q
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.