You are working in a biotech company that has discovered a small-molecule drug c

Question

You are working in a biotech company that has discovered a small-molecule drug called H5 binds to LDL receptors when the) are bound to cholesterol. 115 binding does not alter the conformation of the LDL receptor's intracellular domain. Interestingly, in vitro experiments demonstrate that addition of H5 increases the affinity of Ll)L for cholesterol and prevents cholesterol from dissociating from the LDL receptor even in acidic conditions. Which of the following is a reasonable prediction of what may happen when you add H5 to cells. The LDL receptor will remain on the plasma membrane. The uncoating of vesicles w ill not occur. Cytosolic cholesterol levels will decrease relative to normal cells. Cytosolic cholesterol levels will remain unchanged relative to normal cells.

Explanation / Answer

A. The LDL receptor will remain on the plasma membrane.

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