Question XIII. One of the aspects by which memory B cells active in a secondary
ID: 70292 • Letter: Q
Question
Question XIII. One of the aspects by which memory B cells active in a secondary immune response differ from the naive B-cell population activated in a primary immune response is that
[complete the sentence and assess each subsequent statement (108-114) as either factually correct (= “true”) or incorrect (= “false”)]:
108. the frequency of antigen-specific B cells is lower in a secondary immune response.
109. the antibody produced is of higher affinity in a secondary immune response.
110. the level of somatic hypermutation is higher in a secondary immune response.
111. higher levels of IgM are produced in secondary immune responses.
112. B cells do not require T-cell help in secondary immune responses.
113. memory B cells express higher levels of MHC class II molecules.
114. naive B cells express higher levels of co-stimulatory molecules.
Explanation / Answer
They produce enhanced and immediate effect against the antigen as compared to naïve B cells which took some time to proliferate into plasma cells and memory B cells.
108. False. Because there is high response against antigen in secondary immune response. There is high frequency of antigen-specific B cells in a secondary immune response.
109. True. The antibody produced is of higher affinity in a secondary immune response. This is called affinity maturation.
110. True. the level of somatic hypermutation is higher in a secondary immune response. Because somatic mutation mechanism is activated after exposure to antigen.
111. False. In the primary response the major class of antibody produced is IgM whereas in the secondary response it is IgG (or IgA or IgE)
112. False. Higher level of MHCII allows memory B cell to interact Th cellsmore efficiently at lower doses.
113.True. memory B cells express higher levels of MHC class II molecules. Increased MHCII level facilitate antigen uptake and presentation.
114. False. Because memory B cells are known to express higher levels of co-stimulatory molecules
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