Question X. Cells from the light and dark zone of a germinal center were functio

Question

Question X. Cells from the light and dark zone of a germinal center were functionally tested as well as subjected to a fluorescence-activated cell sorting (FACS) analysis.

The functional testing revealed variable numbers of various leukocyte subsets including B cells, cytotoxic T cells (recognizing peptide-MHC class I complexes), TH2 cells and phagocytosing monocytes/macrophages. The FACS analysis provided this result:

Assess the following statements (74-89) associating the 4 leukocyte subsets with the given quadrant (A, B, C or D), in which the cells in question would appear as either factually correct (= “true”) or incorrect (= “false”)]:

75. Quadrant A: cytotoxic T cells
76. Quadrant A: TH2 cells
77. Quadrant A: phagocytosing monocytes/macrophages

78. Quadrant B: B cells

79. Quadrant B: cytotoxic T cells
80. Quadrant B: TH2 cells
81. Quadrant B: phagocytosing monocytes/macrophages

82. Quadrant C: B cells
83. Quadrant C: cytotoxic T cells
84. Quadrant C: TH2 cells
85. Quadrant C: phagocytosing monocytes/macrophages

86. Quadrant D: B cells
87. Quadrant D: cytotoxic T cells
88. Quadrant D: TH2 cells
89. Quadrant D: phagocytosing monocytes/macrophages

Explanation / Answer

B cells dont hve both markers. They will be in quadrant C.

Tc cells have Cd3 and CD8. They will be in quadrant D.

TH2 cells have both types of markers. They will be in quadrant B.

Monocytes or macrophages have only CD4. They will be in quadrant A.

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