Question II. A biochemist determines the amino acid sequence of the entire light

Question

Question II. A biochemist determines the amino acid sequence of the entire light chain from a purified immunoglobulin produced by a patient whose genome was completely sequenced. From this sequence this scientist is able to establish [complete the sentence and assess each subsequent statement (11-19) as either factually correct (= “true”) or incorrect (= “false”)]:

*note that the question says that the entire light chain was determined and the genome was completely sequenced*

11. the class of immunoglobulin.
12. the light chain isotype.
13. whether the B cell that produced this antibody received T-cell help.
14. the specific variable gene fragment used to produce this chain.
15. the antigen specificity of the immunoglobulin.
16. the number of VDJ rearrangements needed to produce this light chain.
17. the most frequent amino acid present in this light chain.
18. the most frequent amino acid most likely to be present in the associated heavy chain.
19. which antigens cannot react with this immunoglobulin.

Explanation / Answer

11. the class of immunoglobulin Can be established. True
12. the light chain isotype can be established true
13. whether the B cell that produced this antibody received T-cell help can be established. False
14. the specific variable gene fragment used to produce this chain can be established. True
15. the antigen specificity of the immunoglobulin can be established. True
16. the number of VDJ rearrangements needed to produce this light chain csan be established. True
17. the most frequent amino acid present in this light chain can be established. True
18. the most frequent amino acid most likely to be present in the associated heavy chain can be established. False
19. which antigens cannot react with this immunoglobulin can be established. False

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