The oxidation products of ethylene glycol (glycoaldehyde, glycolic acid, and oxa

Question

The oxidation products of ethylene glycol (glycoaldehyde, glycolic acid, and oxalic acid) accumulate in the liver where they interfere with enzymes, resulting in renal failure and severe metabolic acidosis. Metabolism of these molecules continues within the body and calcium oxalate is produced, which crystallizes in the kidneys, and is fatal. This When diagnosed in time, ethylene glycol poisoning is treated by administering ethanol. This treatment allows ethylene glycol to remain unreacted in the body because alcohol dehydrogenase will preferentally react with alcohol and thereby inhibit ethylene glycol dehydrogenase will referentiel to remain unreacted in the metabolism Predict what may happen to people who have impaired liver or kidney function. Would you expect the initial effects to the central nervous system (CNS) be greater or lesser than those with properly functioning organs? Predict the severity of the clinical course of illness in such patients as compared to those with proper functioning liver and kidneys 7.

Explanation / Answer

Impaired kidney functions like chronic kidney disease can lead to several neurological complications. It can happen at various levels of nervous systems including central nervous system such as cognitive dysfunctional, stroke and encephalopathy. These complications has significant effect on moribidity and mortality of patient. Depending on the kind of kindey and liver illness, severity of clinical course can vary. For example, chronic kindey diseaese evolve in five stages. The first two stages are difficult to determine using the standard modification of diet in renal disease. Mostly elderly people are diagnosed in stage 3. It is suggested that diesese can be eliminated at stage 1 and 2 but stage 3, 4 and 5 be simply termed moderate impairment, severe impairment and kidney failure.

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