Which of the following would you predict would happen to a secretory protein if

ID: 69772 • Letter: W

Question

Which of the following would you predict would happen to a secretory protein if the enzyme that cleaves off the signal peptide were inhibited?

Question 9 options:

A) The secretory protein would be anchored in the ER membrane by the signal peptide and would end up in cellular membranes.

B) The ribosome would remain in the cytoplasm and the secretory protein would be released from the ribosome as a cytosolic protein.

C) The secretory protein would be translated at the ER membrane but would not be inserted into the membrane.

What might you infer about a protein of ~100 kDa that cannot enter the nucleus?

Question 10 options:

It is far too large to pass through the nuclear pore

It lacks a NLS.

It functions elsewhere in the cell.

a and c

b and c

It is far too large to pass through the nuclear pore

It lacks a NLS.

It functions elsewhere in the cell.

a and c

b and c

Answer 9: The secretory protein would be anchored in the ER membrane by the signal peptide and would end up in cellular membranes.

Answer 10: e) B and C

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