30) The aqueous extracts of tobacco plants (e.g. Bright, Burley, and Oriental) h

Question

30) The aqueous extracts of tobacco plants (e.g. Bright, Burley, and Oriental) have pH values of 5-6, suggesting the existence of nicotinium ion (the salt form) due to organic acids such as acetic acid (CH3COOH), formic acid (HCOOH) and malic acid (HO2CCH2CHOHCO2H) present in tobacco. During the manufacturing process, tobacco companies often add| ammonium hydroxide to their cigarettes. For instance, Phillip Morris reports up to 0.3 wt% of NH4OH for "flavor enhancement" and as a "processing aid". nicotinium ion nicotine free base What effect does added NHa&OH; have on the ratio of nicotine in its salt versus free base forms? a. b. c. No effect More nicotine will be in its salt form More nicotine will be in its free base form Based on your answer above, what effect does added NH OH have on the absorption of nicotine through the hydrophobic cell membranes in the lungs? Note -molecules must be neutral to passively diffuse across cell membranes. a. b. c. No effect Increased absorption of nicotine Decreased absorption of nicotine

Explanation / Answer

OPTION C IS CORRECT (MORE WILL BE IN ITS BASE FORM)

OPTION B IS CORRECT (INCREASED ABSORPTION OF NICOTINE)

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