The question then asked: Between Fumerate and Malate, which is the more catalyti
ID: 695000 • Letter: T
Question
The question then asked: Between Fumerate and Malate, which is the more catalytically efficient substrate??? I put Fumerate due to it having a higher Kcat/Km value. Please let me knwo what you think. Thank you!
RANGE IN TURNOVER NUMBER x Enzymes vary widely in turnover number Km (M) kca/Km (Sec M1) Substrate H2O2 CO2 kcat (sec 4 x 10 Enzyme 4 x 10 8.3 x 10 1.5 x 107 1.6 x 108 2.8 x 108 3.6 x 10 1.6 x 108 Catalase 1 x 106 1.2 x 102 4 x 105 2.6 x 102 1.4 x 104 9 x 10 5.7 x 10 2 x 105 9.0 x 102 2.5 x 10 8.0 x 102 5 x 106 Carbonic anhydrase HCO3 Acetylcholinesterase Acetylcholine Crotonase Crotonyl-COA Malate Fumarate Glyceraldehyde -3-phosphate Benzylpenicillin benzyloxycarbonyl L-Leu-Gly amide Fumarase Triose phosphate isomerase b-Lactamase 4.3 x 103 1.8 x 105 2 x 103 2 x 105 1.3 x 102 1.5 x 102 2.4 x 108 1 x 108 8.6 x 10- Chymotrypsin Catalase and RuBisCo highest and lowest known TON respectively Most enzymes have TON ranging between 1~105 s-1 under physiological conditionsExplanation / Answer
Ans. [You have done it CORRECT]
When determining the relative efficiency of the same enzyme towards different substrate, the term “catalytic efficiency” is preferred.
Catalytic efficiency = Kcat / Km
Greater is the value of catalytic efficiency for a substrate, the more efficient is the enzyme towards catalysis of that substrate.
Note that, among the given option, the enzyme has highest Kcat/ Km value for substrate Fumarate. So, fumarate is the preferred substrate.
Ans. [You have done it CORRECT]
When determining the relative efficiency of the same enzyme towards different substrate, the term “catalytic efficiency” is preferred.
Catalytic efficiency = Kcat / Km
Greater is the value of catalytic efficiency for a substrate, the more efficient is the enzyme towards catalysis of that substrate.
Note that, among the given option, the enzyme has highest Kcat/ Km value for substrate Fumarate. So, fumarate is the preferred substrate.
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