4 4. What advantage doe s a slow, tight-bonding inhibitor have over a simple rev

Question

4 4. What advantage doe s a slow, tight-bonding inhibitor have over a simple reversible inhibitor? 5. Resistance to your new potent antibacterial drug (1) was shown to be the result of int genetic mutation in the target enzyme such that an important active site a single-po lysine residue was mutated to an aspartate residue, Suggest a simple way to proceed toward the design of a new antibacterial drug against the resistant strain. COOH TH 6. Thromboxane A2 (TXA2) is biosynthesized in humans from prostaglandin H2 (PGH2) by the enzyme thromboxane A2 synthase. Binding of TXA2 to a receptor causes vasoconstriction (raises the blood pressure) and platelet aggregation; therefore, TXAi has been implicated as a causative factor in a number of cardiovascular and renal diseases. A. Without looking at part B of this question, bricfly descrihe threr nnrnaches You

Explanation / Answer

ANSWER TO 5 REDUCE COOH TO CH2OH

THIS HELPS AFTER CH2OH MACING ESTER BOND WITH COOH OF ASPARTATE

AS EARLIER LYSINE WITH NH2 AND COOH OF DRUG USE TO FORM AMIDE

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