Dominant mutations can be categorized according to whether they increase or decr

Question

Dominant mutations can be categorized according to whether they increase or decrease the overall activity of a gene or gene product. Although a loss-of-function mutation (a mutation that inactivates the gene product) is usually recessive, for some genes, one dose of the normal gene product, encoded by the normal allele, is not sufficient to produce a normal phenotype. In this case, a loss-of-function mutation in the gene will be dominant, and the gene is said to be haploinsufficient.

A second category of dominant mutation is the gain-of-function mutation, which results in a new activity or an increased activity or expression of a gene or gene product.

The gene therapy technique currently used in clinical trials involves the "addition" to somatic cells of a normal copy of a gene. In other words, a normal copy of the gene is inserted into the genome of the mutant somatic cell, but the mutated copy of the gene is not removed or replaced.

Will this strategy work for either of the two aforementioned types of dominant mutations?

yes, but only for loss-of-function mutations

yes, but only for gain-of-function mutations

yes, for both types of mutations

no, for neither type of mutation

yes, but only for loss-of-function mutations

yes, but only for gain-of-function mutations

yes, for both types of mutations

no, for neither type of mutation

Explanation / Answer

Yes, this strategy work for either of the two aforementioned types of dominant mutations, but they are only for loss-of-function mutations.

The correct answer is Yes , but only for loss-of-function mutations.

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