Alterations in the ratio of CD4:CD8 lymphocytes are associated with risk of HIV
ID: 68616 • Letter: A
Question
Alterations in the ratio of CD4:CD8 lymphocytes are associated with risk of HIV infection progressing to AIDS, of autoimmune diseases, and of progression of some cancers. In searching for predictors of these effects in normal individuals, researchers have found two independent QTLs in the region of the genome known as the major histocompatibility complex (MHC), one in a region regulating CD8 and the other in a region regulating CD4. What does this indicate for the general population?
Alterations in the ratio of CD4:CD8 lymphocytes are associated with risk of HIV infection progressing to AIDS, of autoimmune diseases, and of progression of some cancers. In searching for predictors of these effects in normal individuals, researchers have found two independent QTLs in the region of the genome known as the major histocompatibility complex (MHC), one in a region regulating CD8 and the other in a region regulating CD4. What does this indicate for the general population?
The probability of an autoimmune disease demonstrates that additive genes are involved. Variation in linkage disequilibrium with one or both of these mutations may increase the risk of autoimmune disease. Autoimmune diseases such as type 1 diabetes are caused by one of these genes. Mutation in one or both of these genes causes HIV and AIDS. Only one mutation can be the cause of rheumatoid arthritis.Explanation / Answer
Variation in linkage disequilibrium with one or both of these mutations may increase the risk of autoimmune diseas
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