Suppose virus A has a viral genome of 19,000 bp, and 10,000,000,000 viruses are

Question

Suppose virus A has a viral genome of 19,000 bp, and 10,000,000,000 viruses are replicated in an infected individual in a single day. Assume that a single mutation at a particular location in the virus A genome is needed for virus A to develop antiviral drug resistance to ledipasvir. The mutation can be a transition or transversion mutation. If RNA polymerase introduces an error in 1 of every 10,000 bases synthesized, how long will it take for virus A to overcome ledipasvir therapy and develop resistance? Round your answer up to a whole number of days.

Explanation / Answer

1010 viruses are synthesized in a single day.

each virus contains 19*103bp viral genome

so total viral genome =19*103*1010

RNA pol introduces 1 mutation in every 104bp

so number of daysto become resistant is=19*1013/104

=19*109 days

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