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PART 3: THE BIGGER PICTURE It is estimat adultho 5% in nort trio. in northern Eu

ID: 67598 • Letter: P

Question

PART 3: THE BIGGER PICTURE It is estimat adultho 5% in nort trio. in northern Europe, to 71% estimated that 75% of adults worldwide show some decrease in lactase activity during od (due to gene regulation). The frequency of decreased lactase activity ranges from in some African and Asian con in Sicily, to more than 90 e This distribution is now thought to have been caused by recent natural selection favoring lactase-persistent individuals in cultures that rely on dairy products. Bacteria that can digest actose exist in your gut. Lactose cannot be directly absorbed through the wall of your small intestine. First, lactose must be digested down into its two parts, glucose and galactose. If you are lactose intolerant, you do not produce an enzyme called lactase which cleaves like the beta-galactosidase enzyme in E. coli. Once you consume gut will come into cont an enzyme called lactase which cleaves lactose much lactose, the bacteria in your ll come into contact with lactose. As shown from the activities and readings above, this starts a cascade of events which results in the digestion of the lactose. 1. Which process (of the ones discussed in Discussion 3) do the bacteria in your gut use to digest lactose? Why? To test for lactose intolerance, blood is taken from the patient every 10 to 15 minutes after ingestion of lactose. Blood glucose levels are measured for each of these time points. Why do they measure blood glucose levels instead of lactose levels? 2. lactose rtolence . Below are blood glucose graphs from two individuals who may be lactose intolerant. Whic of the graphs belongs to a patient with lactose intolerance (circle one)? 50 5 40 a 30 20 50 6 40 20 10 10

Explanation / Answer

1. Bacteria can digest lactose by producing the enzyme beta galactosidase. Lactose degradation needs the presence of the enzyme - galactosidase, which can hydrolyse - galactoside bond and hydrolyse lactos to glucose and galactose.