If guanine is oxidized to 8-oxoguanine it can base pair with Thymine and cause a

Question

If guanine is oxidized to 8-oxoguanine it can base pair with Thymine and cause a transition mutation Adenine and cause a transition mutation Guanine and cause a transversion mutation Adenine and cause a transversion mutation Guanine and cause a transition mutation Thymine-thymine dimers are produced by X-rays Intercalating agents, such as proflavin Alkylating agents Ultraviolet radiation Deaminating agents DNA glycosylases acts in DNA repair by Removing single damaged bases from their sugar Removing methyl and ethyl groups from damaged bases Excising short pieces of DNA, which are then replaced by other repair enzymes Removing bromine atoms from 5-bromouracil Inserting a nucleotide that has been deleted by an intercalating agent In nucleotide excision repair all of the following are involved EXCEPT: DNA polymerase Helicase Endonuclease Photolyase Ligase

Explanation / Answer

38) 8-oxoguanine is the most common DNA lesion resulting from reactive oxygen species and result in a mismatched pairing with Adenine resulting to G to T and C to A substitutions in the genome. So, the answer is (A).

39) Thymine- thymine dimers are produced by UV radiation. So, the answer is (D).

40) DNA glycosylases is associated with base excision repair and acts to cleave N-glycosidic bond. So, the answer is (A).

41) In nucleotide excision repair all except Photolyase because photolyase is involved in UV radiation-mediated damage. So, the answer is (D).

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