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von Willebrand\'s disease is an autosomal recessive blood disorder of dogs cause

ID: 67095 • Letter: V

Question

von Willebrand's disease is an autosomal recessive blood disorder of dogs caused by a deficiency of a protein called vWD. Eighteen allelic variants of the vWD gene have been identified that can cause von Willebrand's disease. Since dogs are diploid animals, any given dog with von Willebrand's disease must have which of the following?
A. Any amount of up to eighteen different vWD alleles.
B. At most, two different vWD alleles.
C. Exactly eighteen vWD alleles.
D. Two copies of the same vWD allele.
E. Exactly nine different vWD alleles.

Explanation / Answer

D. Two copies of the same vWD allele.

Since the disease is autosomal recessive. Therefore to express the disorder condition the two copies of abnormal gene is essentia to be present.