The synthesis of deoxyribonuclotides is controlled by the regulation of ribonucl

Question

The synthesis of deoxyribonuclotides is controlled by the regulation of ribonucleotide reductase. There are two regulatory allosteric sites on the R1 subunit. One regulates the overal activity of the enzyme, and the other regulates the substrate specificity of the enzyme.

For each of these sites, identify the allosteric effectors and their effect on the enzyme activity.

For the site regulating overall activity: (one answer for numbers 1-5)

1. ATP and dATP both stimulate activity.

2. GTP stimulates and dGTP inhibits activity.

3. ATP stimulates and TTP inhibits activity

4. ATP stimulates and dATP inhibits activity

5. ATP inhibits and dATP stimulates activity

These questions below (a - d) it asks to either select stimulate or inhibits for the given condition.

For the site regulating enzyme specificity:

The nucleotide dATP:

a.) Either stimulates or inhibits? the CDP and UDP reduction

The nucleotide TTP:

b.) Either stimulates or inhibits? the GDP reduction

c.) Either simulates or inhibits? the CDP and UDP reduction

The nucleotide dGTP:

d.) Either stimulates or inhibits? the ADP reduction

Explanation / Answer

site regulating overall activity

4. ATP stimulate and dATP inhibits activity

For the site regulating enzyme specificity

A. STIMULATE

B. STIMULATE

C. INHIBITS

D. STIMULATE

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