Predict how a cell would use the pentose phosphate pathway if it requires: 1. Bo

Question

Predict how a cell would use the pentose phosphate pathway if it requires:

1. Both NADPH for biosynthesis and ATP for enery

2. Only ribose 5- phosphate for nucleotides

refer to the following:

A) The oxidative phase produces NADPH plus ribulose 5-phosphate, which is converted to glycolytic intermediates by the non-oxidative phase; these are recycled back to glucose 6- phosphate by gluconeogenesis; the glucose 6-phosphate runs through the oxidative phase to produce more NADPH

B) The oxidative phase produces NADPH plus ribulose 5-phosphate, which isconverted to glycolytic intermediates by the non-oxidative phase and ultimately to pyruvate, making ATP

C) The non-oxidative phase runs in reverse, taking glycolytic intermediates and making ribulose 5-phosphate

D) The oxidative phase produces NADPH plus ribulose 5-phosphate, which is converted to ribose 5-phosphate

E) none of the above

Explanation / Answer

1. Both NADPH for biosynthesis and ATP for energy:

The oxidative phase produces NADPH plus ribulose 5-phosphate, which isconverted to glycolytic intermediates by the non-oxidative phase and ultimately to pyruvate, making ATP

2.. Only ribose 5- phosphate for nucleotides:

The non-oxidative phase runs in reverse, taking glycolytic intermediates and making ribulose 5-phosphate.

Depending upon the requirement of a cell for Ribose-5-phosphate , NADH and ATP pentose phosphate pathway operate in three different ways.

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