1. All of the following are the major cell cycle regulatory proteins except A) p

Question

1. All of the following are the major cell cycle regulatory proteins except

A) protein kinases and protein phosphatases

B) cdk inhibitory proteins (CKIs)

C) Ubiquitin ligases and their activators

D) Gene regulatory proteins

E) Procaspase regulatory protein

2. p53

A) suppresses G1-Cdk activity in G1

B) suppresses G1/S-Cdk and S-Cdk activities following DNA damage in G1

C) is transcriptionally activated by p54

D) promotes transcription of genes that induce cell cycle arrest

E) is transcriptionally inactivated by p54

3. Which of the following is not a true statement?

A) p16 is know as a cyclin-dependent kinase inhibitor

B) p16 is a tumor suppressor protein

C) p16 in humans, is encoded by CDKN2A gene

D) p16 checks the cell cyce at the G1/S phase transition

E) p16 is the major transcriptional target of the tumor suppressor gene, p53

I am really sorry to asking many questions, but I am running out of #of questions that I can ask :(

Explanation / Answer

Q1). E) Procaspase regulatory protein

Q2). B) suppresses G1/S-Cdk and S-Cdk activities following DNA damage in G1

Q3). E) p16 is the major transcriptional target of the tumor suppressor gene, p53

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