All of the following are true about acting treadmilling, EXCEPT for one false st

Question

All of the following are true about acting treadmilling, EXCEPT for one false statement. Which answer is not relevant to actin tradmilling? Filaments of a fixed length still undergo turnover. Treadmilling is powered by actin ATP hydrolysis in the filament. The critical concentration at the two filament ends are different. Certain concentrations of free ATP-actin can simultaneously support assembly at the filament + end and shrinkage at the filament - end . Treadmilling is powered by actin ATP hydrolysis upon dissociation from the filament.

Explanation / Answer

The statement "Certain concentrations of free ATP - actin can simultaneously support assembly at the filament + end and shrinkage at the filament - end is not relevant to actin-tread milling. This is because the free actin - ATP critical concentration is higher than the rate of subunit loss then the filament grows creating ATP rich cap regions. When the critical concentration of ATP-actin is low than subunit loss then the filament undergoes shrinkage. When the critical concentration of ATP-actin of assembly and subunit loss is equal then only it reaches a steady state called tread milling. Hence, option 4 is correct.

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