Using this data could you help me figure out if these genes are linked and if th
ID: 6581 • Letter: U
Question
Using this data could you help me figure out if these genes are linked and if they are what’s the distance between them? Is epistasis involved?This is a dihybrid cross working with fruit flies. Parental generation is a sepia eyed male x apterous female. The F1 are all wild type. The F2 are as follows:
637 +;+
175 +;se
63 ap;+
17 ap;se
Overall F2 ratio observed: 37 wild type: 10 sepia: 3 apterous: 1 apterous sepia
Based on a chi square analysis, do the data fit a 9:3:3:1 ratio? Thank you for any help!!!
Explanation / Answer
Given that,
F2 progeny is
637 +; +
175 +; se
63 ap; +
17 ap; se
Recombinants between wild and sepia are 175
Recombinants between sepia and apterous are 17
Recombinants between wild and apterous are 63
Total progeny are 892
Frequency of recombination between wild and sepia are 175/892 = 0.196
Frequency of recombination between sepia and apterous is 17 / 892 = 0.323
Frequency of recombination between wild and apterous is 63 / 892 = 0.070
So, the distance between the genes is
Sepia-----------------wild--------apterous
ß------0.196------àß---0.070----à
ß----------------0.323----------------à
Overall F2 ratio observed:
37 wild type: 10 wild and sepia: 3 wild and apterous: 1 apterous and sepia
According to chi square analysis the ratio doesn’t fit the 9:3:3:1 ratio.
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