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You have a Drosophila line that is homozygous for autosomal recessive alleles a

ID: 64921 • Letter: Y

Question

You have a Drosophila line that is homozygous for autosomal recessive alleles a and b. You cross females of this line with males homozygous for the corresponding wild-type alleles. You then cross the F1 heterozygous males with their heterozygous sisters. You obtain the following F2 phenotypes (where letters denote recessive phenotypes and pluses denote wild-type phenotypes:

1,400 ++

400 ab

100 a+

100 +b

What is the recombination frequency between a and b? Remember that there is no recombination in male flies. Show your work.

Explanation / Answer

A drosophila line with aabb is crossed with AABB................AABB x aabb

The heterozygotes obtained are................ AaBb.

AaBb males x AaBb females

9:3:3:1 is the mendelian ratio

total flies are: 2000

Recombination frequency = total number of recombinants/ total number of offsprings x 100

Rf= 200/2000 x100 = 20 %

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