Beginning right after the nerve signal opens voltage gated calcium channels in t

Question

Beginning right after the nerve signal opens voltage gated calcium channels in the synaptic knob, place the events at the neuromuscular junction in the correct chronolocigal order as they occur during excitation.

a)

ACh is released into the synaptic cleft.

b)

AChE breaks down ACh, with fragments reabsorbed into synaptic knob.

c)

Two ACh molecules bind to each receptor protein, opening Na+ and K+ channels.

d)

Voltage change in end-plate region opens nearby voltage-gated channels producing an action potential that spreads over muscle surface.

e)

Calcium stimulates exocytosis of ACh from synaptic vessicles.

f)

Nerve stimulation & ACh release stop.

g)

•Na+ enters cell, shifting RMP from -90mV to +75mV, then K+ exits and RMP returns to -90mV.

a)

ACh is released into the synaptic cleft.

b)

AChE breaks down ACh, with fragments reabsorbed into synaptic knob.

c)

Two ACh molecules bind to each receptor protein, opening Na+ and K+ channels.

d)

Voltage change in end-plate region opens nearby voltage-gated channels producing an action potential that spreads over muscle surface.

e)

Calcium stimulates exocytosis of ACh from synaptic vessicles.

f)

Nerve stimulation & ACh release stop.

g)

•Na+ enters cell, shifting RMP from -90mV to +75mV, then K+ exits and RMP returns to -90mV.

Explanation / Answer

e, a, c, g, d, b, f

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