Small G proteins, including Rho, Rac, and Cdc42, contribute to the coordinated m

Question

Small G proteins, including Rho, Rac, and Cdc42, contribute to the coordinated movement and overall polarity of a migrating cell.  Assuming that the cell is migrating in a left-to-right fashion, which of the following is correct?

a.

active Rac at the back of the cell and active Cdc42 in the front of the cell

b.

active Cdc42 at the leading edge of the cell and active Rho at the back of the cell

c.

active Rac at the leading edge of the cell and active Rho at the back of the cell

d.

active Cdc42 at the back of the cell and active Rac at the leading edge of the cell

Explanation / Answer

C. Active Rac at the leading age of the cell and active Rho at the back of the cell. Rho forms actin stress fiber and form focal adhesion. Cdc 42 forms the actin based strucrure near the periphery

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