poliovirus 1. where does poliovirus initially replicate after entry into a host?

Question

poliovirus

1. where does poliovirus initially replicate after entry into a host?

2. what are the two classes of paralytic poliomyelitis? which leads to destruction of motor neurons? which attacks the respiratory centers in the medulla and cranial nerves?

3. what role does VPg protein have in the poliovirus replication cycle?

4. explain the mechanisms used by poliovirus to deactivate host protein translation while still allowing viral protein translation.

5. why is the live/attenuated polio vaccine preferred over killed/inactivated polio vaccine?

6. Jonas Salk patented his vaccine, yielding a personal fortune worth billions os dollors -> true/false

Explanation / Answer

1. After ingestion, the poliovirus initially replicates in the oropharyngeal and intestinal mucosa.

2. Spinal polio and bulbar polio are the two classes of paralytic poliomyelitis. Spinal polio leads to destruction of motor neurons and bulbar polio attacks the respiratory centers in the medulla and cranial nerves.

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