If you introduced a mutation into adenylate kinase that prevented P-loop movemen

Question

If you introduced a mutation into adenylate kinase that prevented P-loop movement and subsequent lid closure, what reaction would you expect the enzyme to catalyze when incubated with AMP and ATP? If you introduced a mutation into adenylate kinase that prevented P-loop movement and subsequent lid closure, what reaction would you expect the enzyme to catalyze when incubated with AMP and ATP? If you introduced a mutation into adenylate kinase that prevented P-loop movement and subsequent lid closure, what reaction would you expect the enzyme to catalyze when incubated with AMP and ATP?

Explanation / Answer

* The enzyme can still bind to ATP and AMP. However, due to lack of P-loop movement and lid closure, the two substrates are not brought to correct position to phosphoryl group transfer. Therefore, phosphoryl group transfer does not occur.

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