GLUT1 and GLUT4 transport glucose into adipose cells and skeletal muscle cells;
ID: 63019 • Letter: G
Question
GLUT1 and GLUT4 transport glucose into adipose cells and skeletal muscle cells; however, GLUT4 is mostly located within intracellular membranes. In response to rising blood glucose levels, the hormone insulin is released. Insulin triggers the movement of GLUT4 to the plasma membrane.
a. What common disease results when GLUT4 does not move to plasma membranes in response to insulin?
b. GLUT1 and GLUT4 have similar Km values for glucose, approximately 4 mM. Insulin stimulation of increases overall glucose uptake by adipose cells by increasing the apparent: (Choose all correct answers.)
Explanation / Answer
a) When GLUT4 does not move to plasma membranes in response to insulin the blood glucose level will not decrease which will lead to diabetes.
b) Insulin triggers the movement of GLUT4 to the plasma membrane. - Which leads to increased overall glucose uptake by adipose cells.
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