The reaction below is part of the TCA cycle. The enzyme that catlyizes this reac

Question

The reaction below is part of the TCA cycle. The enzyme that catlyizes this reaction is called

isocitrate dehydrogenase. It is allostericly regulated negatively by___________________________ and ________________. This is orm of_____________ allows control of this pathway by cells

http://imgur.com/QiHpJmT

(I could not attach the image but i read if i shared it there you guys would be able to look at )

What would happen to the flow of carbon in central metabolism if a-ketogluterate was being removed to make the amino acid glutamate?

The reaction below is part of the TCA cycle. The enzyme that catlyizes this reaction is called

isocitrate dehydrogenase. It is allostericly regulated negatively by___________________________ and ________________. This is orm of_____________ allows control of this pathway by cells

http://imgur.com/QiHpJmT

(I could not attach the image but i read if i shared it there you guys would be able to look at )

What would happen to the flow of carbon in central metabolism if a-ketogluterate was being removed to make the amino acid glutamate?

Explanation / Answer

Isocitrate dehydrogenase (IDH) is an important enzyme in the tricarboxylic acid cycle, which occurs in the mitochondrial matrix.

This enzyme is allosterically regulated negatively by ATP and NADPH, or NADH.

This form of regulation allows control of this pathway by cells.

If alpha-ketoglutarate is removed from the TCA cycle, the intermediate compounds are not formed, which are necessary to produce NADH for carrying out Electron transport chain, and other metabolic compounds necessary for amino acid production. So, ATP production is gradually reduced.

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