The delta 32 mutation/deletion in the CCR5 gene (hereon called CCR5-delta32) off

Question

The delta 32 mutation/deletion in the CCR5 gene (hereon called CCR5-delta32) offers resistance to HIV. Individuals homozygous for this allele are exceptionally resistant to HIV infection. Individuals heterozygous, with one copy of CCR5-delta32 and one normal CCR5 allele have partial resistance to HIV. Individuals homozygous for the normal CCR5 allele have no resistance HIV infection. The increased frequencies of the CCR5-delta32 allele in some European populations may be a result of its similar resistant effects to certain diseases experienced during the numerous plagues in European cities and towns. Having this allele increased odds of survival.

We will use R1 to designate the normal CCR5 allele, and R2 to represent the CCR5-delta32.

If two parents are heterozygous, what is the chance that a child between them could have exceptional resistance?

Complete a Punnett square on your own paper to solve this problem.

0 (0%)

1/4 (25%)

3/4 (75%)

1 (100%)

Explanation / Answer

R1r1 X R1r1

Exclusively resistant is R2R2 it is 1/4 = 25%.

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