1) A common hallmark of Alzheimer\'s disease is the progressive loss of brain fu
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Question
1) A common hallmark of Alzheimer's disease is the progressive loss of brain function that is typically associated with the
Select one:
formation of plaques on the surface of the brain just under the skull.
abnormal accumulation of plaques and tangles inside brain nerve cells.
growth of abnormal sensory nerve endings that form tangles wind around each other.
separation of the two hemispheres of the brain.
unusual tangles of the patient’s hair that grows at the nape of the neck.
2) The pre-cancerous polyps found in the colon during a colonoscopy have the potential to develop into colon cancer if the
Select one:
polyp cells stop growing and enter apoptosis (programmed cell death).
patient fails to get a repeat colonscopy in 3 years.
mitochondrial DNA in the polyp cells is damaged as the polyp is removed.
patient is an Ashkenazi Jew.
chromosome DNA in the polyp cells accumulates additional mutations.
3) The symbols used in a typical pedigree map allow the viewer to determine the
Select one or more:
date of birth of individuals.
cause of death of deceased individuals.
relative ages of cousins shown on the map.
gender of offspring from each generation.
genetic disease patterns within the family.
4) An assay to measure HexA enzyme activity in a maternal blood sample is an example of a genetic test that measures
Select one:
the regulation of HexA gene expression.
the amount of mRNA copied from the HexA gene.
the level that the HexA protein enzyme is expressed in the red blood cell.
the activity of the mutant HexA protein that is the end product of its gene.
the DNA sequence of the HexA gene mutation.
5)DNA chip technology can be used to analyze specific genes that are expressed or transcribed in certain types of cells. In this approach the DNA chip contains an array of many spots containing different DNA sequences that span the entire human genome. A DNA probe used to identify specific genes expressed only in nerve cells can be made by making cDNA copies of
Select one:
RNA from viruses that infect nerve cells.
proteins taken from nerve cells.
fragments of genome DNA taken from nerve cells.
mRNAs taken from nerve cells.
fragments of genome DNA taken from skin cells.
Explanation / Answer
1) A common hallmark of Alzheimer's disease is the progressive loss of brain function that is typically associated with the abnormal accumulation of plaques and tangles inside brain nerve cells.
2) The pre-cancerous polyps found in the colon during a colonoscopy have the potential to develop into colon cancer if the chromosome DNA in the polyp cells accumulates additional mutations.
3) The symbols used in a typical pedigree map allow the viewer to determine the genetic disease patterns within the family.
4) An assay to measure HexA enzyme activity in a maternal blood sample is an example of a genetic test that measures the level that the HexA protein enzyme is expressed in the red blood cell.
5)DNA chip technology can be used to analyze specific genes that are expressed or transcribed in certain types of cells. In this approach the DNA chip contains an array of many spots containing different DNA sequences that span the entire human genome. A DNA probe used to identify specific genes expressed only in nerve cells can be made by making cDNA copies of fragments of genome DNA taken from nerve cells.
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