Thank you in advance, Mrs Jones, age 76 takes an aspirin as anticoagulant therap

Question

Thank you in advance,

Mrs Jones, age 76 takes an aspirin as anticoagulant therapy. When the rheumatologist sees her, she is given a prescription for ibuprofen 800 mg tid for arthritis.

1. Will takeing these two medications together affect the absorption rate of either drug? Please explain your answer in details. 2. What side effects and adverse reactions should Mrs. Joes watch for with aspirin?                                                                3. What are some of the age related polypharmacy problems associated with chronic pain control?

Thank you once again for the help.

Explanation / Answer

Actually Aspirin works by interfering with your blood's ability to form harmful clots and thus hep to prevent heart attacks and stroke and Ibuprofen belong to a class of medications known as NSAIDs (non-steroidal anti-inflammatory drugs) which have the potential to interfere with the protective effect of low-dose aspirin but large dose aspirin say 325mg is not known.

According to the Food and Drug Administration (FDA), it has been suggested that ibuprofen has the potential to interfere with an antiplatelet effect of aspirin. ibuprofen being a reversible inhibitor may have the potential to interact with an irreversible inhibitor by competitive inhibition of the acetylation site of platelet cyclooxygenase (COX). Actually, ibuprofen and aspirin occupy nearby sites on COX and may prevent access and binding of aspirin.

As far as some of the age-related polypharmacy problems with chronic pain control is concerned it is known that there is a predictable age-related decline in cytochrome-450 function and thus bypass of many of the drug-drug interaction is common to the elderly (Kaye et al., 2010). More importantly, Pharmacokinetic and metabolic changes associated with increased age makes the elderly vulnerable to side effects and overdosing associated analgesic agents (Vadivelu et al.,2008).

Related Questions

Navigate

• Browse (All)
• Browse T
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.