1.) What key enzymatic steps get bypassed when fructose enters the glycolytic pa

Question

1.) What key enzymatic steps get bypassed when fructose enters the glycolytic pathway in the liver?

a.) glucokinase only.... b.) glucokinase and phosphofructokinase-1... c.) phosphofructokinase-1 and pyruvate kinase....d.) only pyruvate kinase...... e.) no enzyme steps get bypassed, fructose is metabolized just like glucose.

2.) What is the process of fructolysis consist of and how is it different from glycolysis?

3.) Effect of high liver alanine on pyruvate dehydrogenase activity? a.) increase b.) decrease c.) stay the same..... Please explain. Thank you!!

Explanation / Answer

1.b is the correct option.

In liver, hexokinase enzyme is very low. Glucokinase is present in large amount which acts on glucose, not fructose. So, fructose is first converted to fructose1- phosphate in liver. This fructose 1-phosphate converts to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (3 carbon compounds) which enter the glycolytic pathway. So, both glucokinase and PFK-1 catalysed steps are bypassed.

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