A lab-reared strain of mice is glucose 6-phosphate-insensitive. How would this a

Question

A lab-reared strain of mice is glucose 6-phosphate-insensitive. How would this affect glycogen synthesis? Select the best answer. Glycogen synthesis would remain unchanged because other regulatory mechanisms would be unmasked. Glycogen synthesis would increase because glycogen syntheses would always be active. Glycogen synthesis would increase because a greater insulin concentration would increase glucose transport. Glycogen synthesis would decrease because the b form of glycogen syntheses could not be allosterically activated. Glycogen synthesis would decrease because the usually inactive b form could not be converted to the always-active a form.

Explanation / Answer

The best answer is glycogen synthesis would decrease because the b form of glycogen synthase could not be allosterically activated. In general, glucose 6 phosphate allosterically activates the enzyme glycogen synthase. But as this mice is sensitive to glucose 6 phosphate, glycogen synthase cannot be activated, and as a result glycogen synthesis would decrease.

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