What changes do the promoter and the polymerase undergo during the transition fr

Question

What changes do the promoter and the polymerase undergo during the transition from a closed to an open complex. What drives this transition in prokaryotes, and in eukaryotes? What is the importance of the transition for the overall transcription process? What changes do the promoter and the polymerase undergo during the transition from a closed to an open complex. What drives this transition in prokaryotes, and in eukaryotes? What is the importance of the transition for the overall transcription process? What changes do the promoter and the polymerase undergo during the transition from a closed to an open complex. What drives this transition in prokaryotes, and in eukaryotes? What is the importance of the transition for the overall transcription process?

Explanation / Answer

RNA polymerase binds to the promoter to form a closed complex where DNA strands remain together. The polymerase-promoter complex then undergoes a transition, which is a melting or unwinding of about 12 bp and the polymerase is positioned to initiate transcription.

Elongation factor (EF-G in prokaryotes and EF-2 ineukaryotes) drives this transition in prokaryotes, and in eukaryotes.

Transition from closed to open complex results in separation of the two DNA strands and the positioning of the template strand to the active site of the RNA polymerase. Without primer, RNA polymerase cannot bind and initiate the transcription process.

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