Describe the roles of the different subunits of the E.coli RNA polymerase. How d

Question

Describe the roles of the different subunits of the E.coli RNA polymerase. How do each of them interact with the other polymerase subunits, and with the various promoter elements? What is the difference between the RNA polymerase "core" enzyme and the "holoenzyme". Describe the roles of the different subunits of the E.coli RNA polymerase. How do each of them interact with the other polymerase subunits, and with the various promoter elements? What is the difference between the RNA polymerase "core" enzyme and the "holoenzyme". Describe the roles of the different subunits of the E.coli RNA polymerase. How do each of them interact with the other polymerase subunits, and with the various promoter elements? What is the difference between the RNA polymerase "core" enzyme and the "holoenzyme".

Explanation / Answer

The core enzyme has a molecular weight of approximately 400 kDa. E. coli RNA Polymerase Holoenzyme is the core enzyme saturated with sigma factor 70. The Holoenzyme initiates RNA synthesis from sigma 70 specific bacterial and phage promoters.

Initiation of transcription is a complicated process involving several different phases: promoter location by RNA polymerase, formation of a competent initiation complex, synthesis of the initial phosphodiester bonds, and movement of RNA polymerase from the promoter as it enters the elongation phase;

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