1. The impossibility of zero-calorie beer (6) Ethanol that we consume is oxidize
ID: 591300 • Letter: 1
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1. The impossibility of zero-calorie beer (6) Ethanol that we consume is oxidized to acetate in the liver, which is then converted to acetyl-CoA and further metabolized to 2 CO2 Determine how many molecules of ATP (or equivalent) are produced from the complete oxidation of one molecule of ethanol to 2 CO2 Assume that 1 ATP molecule is consumed to form acetyl-CoA from acetate and CoA Reactions for the metabolism of ethanol to acetate are in the textbook, p.342. Use P:O ratios of 2.5 ATP per NADH and 1.5 ATP per for QH2 Show your reasoning!Explanation / Answer
In the presence of enzymes alcohol dehydrogenase and acetaldehyde dehydrogenase, ethanol is converted into acetaldehyde and acetate respectively and both use NAD+ and oxidant.
Therefore in the cytosol, 2 NAD are produced.
Depending on the movement of electrons into the mitochondria, 1.5 ATP are produced per NADH, so conversion of ethanol into acetate 3 ATP are produced.
During conversion of ethanol into acetyl-CoA, further produced 2CO2 and 1 ATP molecule.
Complete oxidation of acetyl-CoA in the TCA cycle produced 10 ATP molecules in which
3 NADH produced 2.5 ATP each;
1 FADH2 produced 1.5 ;
1 GTP
Ethanol oxidation thus produced= 11 ATP or
=11 ATP/2 carbons
= 5.5 ATP/ carbon
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