I believe that the answer is on the lagging strand, but I\'m confused about the

Question

I believe that the answer is on the lagging strand, but I'm confused about the "in two directions" option here. Could someone clarify?

In the laboratory, some E. coli cells have been grown with transcription inhibitors so that only replication could occur. You break open the cells; gently purify the DNA, separating it from the rest of the cell contents; then treat the intact DNA with radioactively labelled antibodies to DNA ligase and DNA polymerase I. Where do you expect to find the highest concentration of these enzymes?

A. On the leading strand, in one direction from the point of origin

B. On the leading strands, in both directions from the point of origin

C. On the lagging strand, in one direction from the point of origin

D. On the lagging strands, in both directions from the point of origin

E. On all parts of the DNA molecule equally

Explanation / Answer

D. On the lagging strands, in both directions from the point of origin

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