Problem 3 A study of cannabinoid receptor ligands revealed the following Hansch

Question

Problem 3 A study of cannabinoid receptor ligands revealed the following Hansch equation for variation of substituent X: M RA Log 1/C-251 + 0.14s + 7.66 Cl CI a) Explain how the substituent X will influence the binding affinity of the b) Would you expect the amino analogue (X- NH2) to exhibit higher or lower c) Calculate the theoretical ICso values for the NH2 and Cl analogues. ligand and what chemical properties (e.g. electronic, hydrophilic...) are most important at this position in the molecule. affinity than the chloro analogue (X- CI)?

Explanation / Answer

there would be more interaction with the amino group when compared with the chlorine group, this is why because amino group can form hydrogen bond and it will interaction more. so it has more affinity with the ligand.

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