How does nondisjunction in human female gametes give rise to Klinefelter and Tur

Question

How does nondisjunction in human female gametes give rise to Klinefelter and Turner syndrome offspring following fertilization by a normal male gamete?

A. Nondisjunction results in ova that carry either two X chromosomes or none. An ovum with two X chromosomes results in Klinefelter syndrome when fertilized by a Y-containing sperm, and in Turner syndrome when fertilized by an X-containing sperm.

B. Nondisjunction results in ova that carry either two X chromosomes or none. An ovum with no X chromosomes results in Klinefelter syndrome when fertilized by a Y-containing sperm, and in Turner syndrome when fertilized by an X-containing sperm.

C. Nondisjunction of complete sets of chromosomes leads to ova that are either diploid, or completely devoid of chromosomes. A diploid ovum results in Klinefelter syndrome when fertilized by a Y-containing sperm, and results in Turner syndrome when fertilized by an X-containing sperm.

D. Nondisjunction results in ova that carry either two X chromosomes or none. The former results in Klinefelter syndrome when fertilized by a Y-containing sperm, and the latter results in Turner syndrome when fertilized by an X-containing sperm.

E. Nondisjunction results in ova that carry either two X chromosomes or none. The former results in Turner syndrome when fertilized by a Y-containing sperm, and the latter results in Klinfelter syndrome when fertilized by an X-containing sperm.

Explanation / Answer

Nondisjunction of chromosomes in human beings leads to clinical syndrome caused due to Trisomy in humanbeings.

Klinfilter syndrome caused due to trisomy in 47 position.

1) 47, XXY there are 2X and 1Y chromosomes formula is 2n+1

2) 48 XXXY there are 3X and 1Y chromosomes formula is 2n+2

3) 48 XXYY there are 2X and 2Y chromosomes formula is 2n+2

4) 49 XXXXY there are 4X and 1Y chromosomes formula is 2n+3

5) 50 XXXXXY there are 5X and 1Y chromosomes formula is 2n+4.

whereas in Turners syndrome is seen in the condition of monosomy when one chromosome is missing in the diploid individual

22chromosomes of egg cross with 23,X chromosomes of sperm _______ 45,X chromosomes called turners syndrome.

when 23 X of egg and 23 X of sperm cross leads to 46,XX and 45,X ----------leading to monosomic condition loss of X chromosome takes place.

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