Figure 2: Mechanism of the G2 checkpoint (Figure 5.5 of Pecorlno 3rd edition) Wh

Question

Figure 2: Mechanism of the G2 checkpoint (Figure 5.5 of Pecorlno 3rd edition) What happens to cdk activity if there is DNA damage? Does the cell progress to M phase? You are trying to develop a drug that activates ATM .You develop a series of hypotheses to test if you are successful Answer the following questions: What do you predict will happen to the activity of cdc25 if you add the drug? What do you predict will happen to the phosphorylation level of cdk if you add the drug? What will happen to the cell cycle if you add the durg?

Explanation / Answer

a. CDK activity will be increased to DNA damage response and involve in DNA repair by downstream regulation. Yes, it does enter into M phase of the cell cycle after DNA repair.

b.

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